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KMID : 0363319940150010045
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Journal of Korean Oriental Internal Medicine
1994 Volume.15 No. 1 p.45 ~ p.59
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Effects of the Ijintang, Sagoonjatang, and Yuggoonjatang on the Hyperlipidemia induced Rabbits
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Lee Seung-Jae
Moon Byung-Soon
Kim Seh-Gil
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Abstract
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The present experiments were designed to investigate the effect of Ijntang, Sagoonjatang, and Yuggoonjatang on the hyperlipidemia induced rabbit. In order to control the precise chemical and physical condition, the experimental rabbits were supplied with calory limited food. The Hyperlipidemia rabbits were induced by oral administration of cholesterol (250mg/kg) for 4 weeks.
The results were as followings :
1. The hyperlipidemia (control) group increased the concentration of serum glucose to 204.1±2.63 ㎎/㎗ at the 4th. week, however, the other drug administrated groups such as Ijintang, Sagoonjatang, and Yuggoonjatang decreased significantly.
2. The control group increased the concentration of serum totalcholesterol to 299.0±4.18 ㎎/㎗ at the 4th. week, however, the other drug administrated groups Ijintang, Sagoonjatang, and Yuggoonjatang decreased significantly.
3. The control group increased the concentration of serum total lipid to 429.1±1.72 ㎎/㎗ at the 4th. week, however, the other drug administrated groups such as Ijintang, Sagoonjatang, and Yuggoonjatang decreased significantly.
4. The control group increased the concentration of serum triglyceride to 149.3±3.01 ㎎/㎗ at the 4th. week, however, the other drug administrated groups such as Ijintang, Sagoonjatang, and Yuggoonjatang decreased significantly.
5. The control group increased the concentration of serum HDL-cholesterol to 83.0±1.09 ㎎/㎗ at the 4th. week, and, the other drug administrated groups such as Ijintang, Sagoonjatang, and Yuggoonjatang increased significantly.
6. The lipid deposition to the aortic endothelium decreased more at the Yuggoonjatang group than the other groups.
According to the above experimental results, Yuggoonjatang is assumed to have a more curative effect against hyperlipidemia than the other drug such as Ijintang and Sagoonjatang.
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